Mechanisms of action and resistance for multiple myeloma novel drug treatments

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Molecular mechanisms in multiple myeloma drug resistance.

Multiple myeloma (MM) is predominantly an incurable malignancy despite high-dose chemotherapy, autologous stem cell transplant and novel agents. MM is a genetically heterogeneous disease and the complexity increases as the disease progresses to a more aggressive stage. MM arises from a plasma cell, which produces and secretes non-functioning immunoglobulins. Most MM cells are sensitive to prote...

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Multiple myeloma (MM) is a hematological malignancy that remains incurable because most patients eventually relapse or become refractory to current treatments. Although the treatments have improved, the major problem in MM is resistance to therapy. Clonal evolution of MM cells and bone marrow microenvironment changes contribute to drug resistance. Some mechanisms affect both MM cells and microe...

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Cardiovascular Complications of Novel Multiple Myeloma Treatments.

Case presentation: A 75-year-old woman was referred to cardiology for optimization of cardiovascular risk factors before starting a new cancer treatment. She was diagnosed with IgG-κ multiple myeloma (MM) 2 years previously that progressed after her previous treatments. Her medical history also included type 2 diabetes mellitus, hypertension, and a remote history of deep vein thrombosis treated...

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Novel Mechanisms of Action for Immunomodulatory Drugs Against Multiple Myeloma : from a Tragedy to a Therapy

Thalidomide, a sedative to ease morning sickness in pregnant women, was banned more than a half century ago due to causing a severe birth defect known as phocomelia. However, the late discovery of its immunomodulatory properties have led to a new era in the treatment of Multiple Myeloma (MM), a fatal disease that back then had no effective therapy available. The recent development and FDA-accel...

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ژورنال

عنوان ژورنال: International Journal of Hematology

سال: 2016

ISSN: 0925-5710,1865-3774

DOI: 10.1007/s12185-016-2040-0